statins are well known for their cholesterol-reducing capability, that could assist lessen the threat of cardiovascular disease. however in step with a new study, statins may also have the capacity to decrease the risk of Alzheimer’s disease.
published in JAMA Neurology, the look at identifies a hyperlink among high statin use and a lower chance of Alzheimer’s ailment, even though the reduced risk is dependent on sex, race/ethnicity, and the type of statin used.
while the study is only observational, the studies team – which includes Julie M. Zissimopoulos, Ph.D., of the university of Southern California in los angeles – and colleagues say that the findings must be further investigated in medical trials.
Alzheimer’s disorder is the maximum common shape of dementia, with round 5.2 million humans within the usa aged 65 and older residing with the disorder. through 2050, this range should attain 13.8 million, except new prevention or treatment techniques are found.
while great strides were made within the search for ways to halt the improvement and development of Alzheimer’s in recent years, researchers are but to jump the final hurdle.
just last month, hopes of the first medication to gradual Alzheimer’s had been dashed, after drug large Eli Lilly announced that their promising drug candidate solanezumab had failed to reduce cognitive decline in a phase III trial of patients with the disease.
within the new study, Zissimopoulos and crew propose it might be really worth investigating the feasibility of existingpills for the prevention of Alzheimer’s, after locating a link between excessive publicity to statins and decreased Alzheimer’s risk.
Statins and Alzheimer’s
Statins are often prescribed to lower ranges of low-density lipoprotein cholesterol – “awful” cholesterol that may increase the risk of heart attack and stroke.
in keeping with Zissimopoulos and associates, preceding studies have proven that high cholesterol levels can be related to the buildup of beta-amyloid plaques in the brain, which might be considered to be an indicator of Alzheimer’s disease.
As such, the researchers hypothesized that cholesterol-reducing medicinal drugs may affect the onset of Alzheimer’s and its next development.
to research their concept, the crew analyzed 2006-2013 Medicare information of 399,979 adults elderly 65 and older who had used statins.
The researchers looked at how low and high statin use might be associated with risk of an Alzheimer’s diagnosis between 2009-2013. high statin publicity become described as “at least the 50th percentile of days of stuffed prescriptions in a given year for at the least 2 years during 2006, 2007, and 2008.”
every 12 months between 2009-2013, round 1.seventy two percent of girls and 1.32 percent of guys were identified with Alzheimer’s, with prognosis lowest among white men, at 1.23 percentage.
basic, males and females with high publicity to statins were 15 percent and 12 percent less likely to be identified with Alzheimer’s, respectively, in comparison with men and women with low publicity to the medication.
but, on closer investigation, the team discovered that the hyperlink between high statin use and decrease Alzheimer’s chance was dependent on sex, race/ethnicity, and the type of statin used.
Alzheimer’s chance depending on statin type, sex, race/ethnicity
high exposure to statins ordinary was best related to a reduced chance of Alzheimer’s for Hispanic men, black ladies, and white women and men, as compared with low exposure to the drugs.
Breaking the statistics down further by statin kind, the researchers found that:
- highatorvastatin publicity was linked to reduced Alzheimer’s risk for white and black ladies, as well as for Hispanic women and men
- White, Hispanic, and blackwomen had a lower Alzheimer’s threat with high use of simvastatin, as did white and Hispanic men
- Pravastatin and rosuvastatinwere related to a reduced danger of Alzheimer’s for white girls.
For black men, the crew recognized no huge discount in Alzheimer’s risk with the usage of any statin.
The researchers pressure that their examine is unable to show reason and effect, so medical trials are required – related to all racial and ethnic businesses – to confirm their results.
still, they agree with their findings suggest that sure statins can be a feasible approach to fight Alzheimer’s disease:
“Our look at identified the institutions between ad [Alzheimer’s disease] incidence and statin use by statin kind, sex, and race/ethnicity. This indicates that certain patients, dealing with a couple of, otherwise same statin options for hyperlipidemia treatment, may reduce advert danger with the aid of using a particular statin.
The proper statin kind for the proper person on the right time may also offer a noticeably inexpensive manner to reduce the load of AD.”